Description

Xeloda (Capecitabine) 500mg – 120 Tablets

Xeloda (capecitabine) is an oral chemotherapy medication widely prescribed for the treatment of various cancers. It is often chosen as an alternative to intravenous chemotherapy due to its oral administration convenience.

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What is Xeloda (Capecitabine)?

Xeloda is a prodrug of 5-fluorouracil (5-FU), which means it becomes active only after being metabolized in the body. Once converted, it works by:

• Inhibiting thymidylate synthase – blocking DNA synthesis and repair in cancer cells.

• Disrupting RNA and DNA functions – leading to cancer cell death.

• Targeting tumor tissues – because the enzyme thymidine phosphorylase (responsible for conversion) is more highly expressed in cancer cells.

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Indications (Uses of Xeloda)

Xeloda 500mg is commonly used in the treatment of:

• Adjuvant colon cancer

• Metastatic colorectal cancer

• Metastatic breast cancer

• Pancreatic adenocarcinoma (as part of combination chemotherapy)

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Product Details – Xeloda 500mg 120 Tablets

• Strength: 500mg

• Quantity: 120 tablets per bottle

• Appearance: Oblong, biconvex, peach-colored, film-coated tablets with “XELODA” on one side and “500” on the other

• Administration: Swallow whole with water, within 30 minutes after a meal

• Important Note: Do not crush, chew, or split the tablets

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Recommended Dosage

• Starting dose: 1,250 mg/m² orally twice daily (morning and evening) for 2 weeks, followed by a 1-week rest period

• Dose adjustments: May be rounded to the nearest 150mg for whole tablets

• Administration guidelines: Always take after meals and follow your doctor’s exact instructions

• Storage: Keep at room temperature (20°C–25°C / 68°F–77°F), away from light and moisture

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Safety & Handling Precautions

Since Xeloda is a cytotoxic drug, special care is needed when handling:

• Personal Protection: Wear protective gloves (nitrile, neoprene, or butyl rubber), protective clothing, and eye/face protection.

• Pregnancy Warning: Pregnant women should not handle Xeloda due to potential risks to the unborn baby.

• Disposal: Follow local/national cytotoxic drug disposal regulations. Do not dispose in household trash.

• Interactions: Use with caution if taking blood thinners (e.g., warfarin)—requires close monitoring.

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Common Side Effects of Xeloda

Like most chemotherapy medications, Xeloda may cause side effects. The most frequently reported include:

• Hand-foot syndrome (redness, swelling, peeling of skin)

• Diarrhea

• Nausea & vomiting

• Fatigue & weakness

• Abdominal pain or discomfort

• Skin rashes

Always report any severe or persistent side effects to your healthcare provider.

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Why Patients Prefer Xeloda

• Oral convenience: No need for IV infusions

• Flexible dosing: Can be adjusted based on tolerance

• Proven effectiveness: Widely used in breast, gastric, and colorectal cancer treatment

• Improved quality of life: Many patients find oral therapy easier to manage at home

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Availability & Shortage Update

Xeloda 500mg (120 tablets) is currently experiencing a shortage in some regions. Prices may vary between online pharmacies and local U.S. pharmacies. Patients should check availability and consult healthcare providers for alternatives if needed.