Description

Trajenta 5 mg (Linagliptin) Tablets – Uses, Dosage, Side Effects & Price in Pakistan

Trajenta 5 mg tablets contain Linagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor used as an adjunct to diet and exercise for the management of type 2 diabetes mellitus in adults. It helps improve glycemic control by increasing insulin secretion and reducing glucose production in the body.

This imported medicine is available in packs of 30 film-coated tablets.

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Key Benefits of Trajenta 5 mg

• Effective Glycemic Control – Helps reduce blood sugar levels and HbA1c in type 2 diabetes patients.

• Versatile Use – Can be prescribed as monotherapy (when metformin is unsuitable) or in combination with metformin, sulfonylureas, or insulin for better results.

• Convenient Once-Daily Dosing – Only one tablet (5 mg) daily, with or without food.

• No Dose Adjustment Required – Suitable for patients with renal impairment, hepatic impairment, or elderly patients.

• Well-Tolerated – Minimal side effects and no major changes in laboratory parameters compared to placebo.

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How Trajenta (Linagliptin) Works

• Mechanism of Action:

  • Linagliptin inhibits the DPP-4 enzyme, preventing the breakdown of incretin hormones (GLP-1 and GIP).

  • This leads to higher incretin levels, which stimulate insulin release and suppress glucagon secretion in a glucose-dependent manner.

  • Reduces blood glucose without causing severe hypoglycemia.

• Active Ingredient: Linagliptin (C₂₅H₂₈N₈O₂, MW: 472.54 g/mol)

• Pharmacological Class: DPP-4 Inhibitor

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Recommended Dosage & Administration

• Standard Dose: 5 mg tablet once daily (with or without food).

• Combination Therapy:

  • With metformin – continue metformin dose, add Trajenta 5 mg.

  • With sulfonylurea or insulin – dose reduction of sulfonylurea/insulin may be considered to reduce risk of hypoglycemia.

• Administration: Swallow tablets whole with water. Do not chew, crush, or break.

• Missed Dose: Take as soon as remembered. Do not double the dose.

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Possible Side Effects of Trajenta

Common Side Effects:

• Hypoglycemia (especially with insulin or sulfonylureas)

• Nasopharyngitis (cold, sore throat)

• Cough, diarrhea, constipation

• Vomiting, mild stomach upset

Rare but Serious Side Effects:

• Pancreatitis

• Angioedema (swelling of face, lips, or throat)

• Severe joint pain

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Warnings & Precautions

• Not for Type 1 Diabetes or diabetic ketoacidosis.

• Monitor blood glucose regularly when used with insulin or sulfonylureas.

• Safety in children and adolescents not established.

• Use with caution in patients with history of pancreatitis.

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Storage Instructions

• Store at room temperature (no special storage required).

• Keep in original packaging, away from light and moisture.

• Keep out of reach of children.