Description

Sandimmun Neoral 25mg Capsules (50’s) – Uses, Dosage, Benefits & Side Effects

Sandimmun Neoral 25mg Capsules (Cyclosporine) are an immunosuppressant medication manufactured by Novartis. They are primarily used to prevent organ rejection after a kidney, liver, or heart transplant, and also for the treatment of severe autoimmune conditions such as rheumatoid arthritis and plaque psoriasis.

What is Sandimmun Neoral?

• Brand Name: Sandimmun Neoral

• Generic Name: Cyclosporine

• Drug Class: Calcineurin Inhibitor (Immunosuppressant)

• Available Strengths: 25mg and 100mg capsules

• Pack Size: 50-count bottle

The 25mg capsules are blue-gray, oval-shaped, and imprinted with “NEORAL 25mg”.

Ciclosporin

Immunosuppressant medication

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Uses

Used for rheumatoid arthritis, psoriasis, Crohn’s disease, nephrotic syndrome, eczema, organ transplants to prevent rejection, and as eye drops for dry eyes.

Administration

Can be administered orally, intravenously, or as eye drops.

Drug Class

Calcineurin inhibitor

According to the search results, the key points about the chemical structure of cyclosporine, the active ingredient in Sandimmun Neoral, are:Molecular Formula and Mass
The molecular formula of cyclosporine is C62H111N11O12, with a molecular mass of 1202.64 g/mol.Structural Formula
Cyclosporine has a cyclic structure composed of 11 amino acids. The structural formula is described as:
(R-[R*,R*-(E)]]-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).Also Known As
Cyclosporine is also known as cyclosporin A and ciclosporin.

Key Medical Uses

1. Prevention of Organ Transplant Rejection

   • Helps prevent the immune system from rejecting a kidney, liver, or heart transplant.

2. Autoimmune Disease Treatment

   • Used in severe rheumatoid arthritis and plaque psoriasis cases where other treatments are ineffective.

3. Improved Absorption

   • Compared to the older formulation (Sandimmune), Sandimmun Neoral offers better bioavailability, ensuring more reliable blood concentrations.

How Sandimmun Neoral Works

Sandimmun Neoral contains Cyclosporine, which acts by:

• Suppressing T-cell activation to reduce immune response.

• Inhibiting the release of lymphokines (including interleukin-2).

• Blocking lymphocyte activity in the G0/G1 phase of the cell cycle.

• Providing specific and reversible immunosuppression, unlike cytotoxic drugs that damage bone marrow.

Recommended Dosage

• Organ Transplantation:

  • Initial dose: 7–9 mg/kg/day orally, divided into two doses.

  • Dose adjusted based on blood cyclosporine levels.

• Rheumatoid Arthritis & Psoriasis:

  • Starting dose: 1.25 mg/kg twice daily.

  • Can be increased up to a maximum of 4 mg/kg/day if required.

👉 Always follow your doctor’s dosing instructions and regular monitoring.

Composition & Ingredients

Each Sandimmun Neoral 25mg capsule contains:

• Active Ingredient: Cyclosporine 25mg

• Excipients: Gelatin, medium-chain triglycerides, polyoxyl 40 hydrogenated castor oil, ethanol, propylene glycol, corn oil-mono-di-triglycerides, butylhydroxytoluene.

Side Effects of Sandimmun Neoral

Like all immunosuppressants, Sandimmun Neoral may cause side effects, including:

• Common: High blood pressure, kidney problems, tremors, headache, increased infection risk.

• Serious (less common): Liver dysfunction, gum overgrowth, high potassium, seizures.

👉 Regular monitoring of blood pressure, kidney function, and cyclosporine levels is required during treatment.

Storage Guidelines

• Store at room temperature (15–30°C).

• Keep away from moisture and direct sunlight.

• Do not refrigerate or freeze oral solution.

Key Benefits of Sandimmun Neoral 25mg Capsules

✔ Prevents organ transplant rejection (kidney, liver, heart)
✔ Effective in treating rheumatoid arthritis & psoriasis
✔ Provides better bioavailability compared to older formulations
✔ Offers specific, reversible immune suppression without bone marrow suppression