Description

Temoside 100mg Capsules (5’s Pack) – Uses, Dosage, Side Effects & Safety

Overview

Temoside 100mg Capsules (5’s pack) contain temozolomide, an oral chemotherapy medication used for the treatment of aggressive brain cancers, including glioblastoma multiforme (GBM) and anaplastic astrocytoma.

Temoside works by interfering with DNA replication in cancer cells, causing them to stop growing and eventually die. This makes it a standard treatment option for patients undergoing chemoradiotherapy and maintenance therapy.

⚠️ Because temozolomide is a hazardous drug, special handling and disposal precautions are required.

Indications

Temoside 100mg capsules are prescribed for:

• Glioblastoma Multiforme (GBM): Newly diagnosed cases, used in combination with focal radiotherapy, followed by maintenance treatment.

• Anaplastic Astrocytoma: For adults whose cancer has progressed despite prior treatments with nitrosoureas and procarbazine.

Dosage & Administration

• Recommended Dose: 150–200 mg/m² of body surface area, taken orally once daily.

• Duration: Typically 42–49 days, in combination with radiotherapy for certain brain cancers.

• Administration:

  • Take on an empty stomach (1 hour before or 2 hours after meals).

  • Swallow capsules whole—do not crush or open.

  • Dosage adjustments may be required based on patient response and blood counts.

Mechanism of Action

• Prodrug Activation: Temozolomide is converted in the body to its active form, MTIC (5-(3-methyltriazen-1-yl)imidazole-4-carboxamide).

• DNA Alkylation: MTIC adds methyl groups to DNA, mainly at the O6 and N7 guanine positions.

• Cancer Cell Death: This DNA damage prevents cancer cell division, leading to apoptosis (programmed cell death).

Key Features of Temoside 100mg Capsules

• Imported medication available in Pakistan.

• Pack size: 5 capsules.

• Active ingredient: 100mg of temozolomide per capsule.

• Treatment use: Brain cancers (GBM & anaplastic astrocytoma).

• Mode of action: Kills cancer cells, slows tumor growth, and prevents spread.

• Combination therapy: Often prescribed alongside focal radiotherapy.

• Hazardous drug: Requires protective handling and special disposal procedures.

Clinical Benefits

• Proven to improve progression-free survival and overall survival in patients with aggressive brain tumors.

• Works effectively in combination with radiotherapy.

• Provides a targeted chemotherapy option for difficult-to-treat brain cancers.

Side Effects

Common:

• Nausea and vomiting

• Fatigue

• Headache

• Constipation

• Loss of appetite

Serious (require medical attention):

• Myelosuppression (low white blood cell, platelet, or red blood cell counts)

• Increased risk of infections

• Severe allergic reactions or rashes

Regular blood count monitoring is essential during treatment.

Storage Instructions

• Store below 25°C in a cool, dry place.

• Keep away from light, heat, and moisture.

• Keep out of reach of children and pets.

Safety Precautions

• Handle capsules with gloves to avoid direct contact.

• Do not crush or open capsules to prevent exposure to the powder.

• Dispose of unused capsules according to pharmacist or oncologist instructions—do not throw in household trash.

• Pregnancy & Breastfeeding: Contraindicated due to risks of birth defects and infant harm. Women of reproductive potential should use effective contraception during treatment and for 6 months after the last dose.

Conclusion

Temoside 100mg Capsules (5’s pack) are a trusted chemotherapy treatment for glioblastoma multiforme and anaplastic astrocytoma. Containing temozolomide, they work by damaging DNA in cancer cells, preventing tumor growth and spread. While highly effective, they require strict medical supervision, safe handling, and regular monitoring to minimize risks.