Description

Soranib 200mg Tablets (30’s Pack Imported) – Uses, Dosage, Side Effects & Price in Pakistan

Overview

Soranib 200mg Tablets (30 count, Imported) contain sorafenib, a multi-kinase inhibitor used in the treatment of advanced cancers. It is primarily prescribed for renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer), and differentiated thyroid carcinoma that does not respond to radioactive iodine therapy.

Sorafenib works by blocking tumor cell growth and angiogenesis (blood vessel formation), slowing the spread of cancer and improving survival outcomes in many patients.

Composition

• Active Ingredient: Sorafenib (200mg per tablet)

• Drug Class: Multi-kinase inhibitor (oral chemotherapy)

• Mechanism of Action: Blocks multiple receptor tyrosine kinases (VEGFR, PDGFR, RAF kinases, FLT-3, RET, c-KIT), disrupting tumor growth and blood supply.

Indications

Soranib 200mg Tablets are indicated for:

• Advanced Renal Cell Carcinoma (RCC) – kidney cancer.

• Unresectable Hepatocellular Carcinoma (HCC) – liver cancer in patients who cannot undergo surgery.

• Differentiated Thyroid Carcinoma (DTC) – thyroid cancer resistant to radioactive iodine treatment.

Dosage & Administration

• Recommended Dose: 200mg tablet twice daily (total 400mg/day).

• Administration:

  • Can be taken with or without food.

  • Tablets should be swallowed whole; do not crush, chew, or break.

• Dosage Adjustments: May be required depending on patient tolerance, liver/kidney function, and treatment response.

Clinical Evidence

Hepatocellular Carcinoma (HCC)

• FDA approved sorafenib in 2007 as the first systemic drug for unresectable HCC.

• SHARP & Asia-Pacific Trials:

  • Median overall survival (OS): 10.7 months vs 7.9 months (placebo).

  • Median time to progression: 5.5 months vs 2.8 months (placebo).

Real-World Effectiveness

• Median progression-free survival (PFS): 2.9 months.

• Median overall survival (OS): 8.5 months.

• Still provides meaningful benefit, though newer therapies may achieve longer survival.

Key Benefits of Soranib 200mg Tablets

• Treats advanced kidney, liver, and thyroid cancers.

• Inhibits tumor growth by blocking multiple kinases.

• Reduces cancer-related blood vessel formation.

• Proven to delay disease progression and improve survival in clinical trials.

Side Effects

Common:

• Nausea, diarrhea, fatigue

• Skin rash, redness, or dryness (hand-foot skin reaction)

• Weight loss, appetite loss

• High blood pressure

Serious (require medical attention):

• Bleeding complications

• Severe liver problems

• Heart rhythm disturbances (QT prolongation)

• Wound healing delays

Safety & Precautions

• Pregnancy: Contraindicated; may cause fetal harm. Women should use effective contraception during treatment and for 6 months after the last dose.

• Breastfeeding: Not recommended during treatment and for 2 weeks after the final dose.

• Liver & Lung Conditions: Use with caution in patients with severe liver disease or lung disorders.

• Blood Pressure & Heart Health: Monitor regularly; Soranib may cause hypertension and heart rhythm issues.

• Surgery: Inform your doctor before planned procedures, as Soranib may delay wound healing.

• Alcohol & Driving: Avoid alcohol; do not drive if experiencing dizziness or neurological side effects.

Packaging & Storage

• Pack Size: 30 tablets (Imported).

• Storage: Keep at room temperature, away from heat, light, and moisture.

• Child Safety: Store out of reach of children.

Price of Soranib 200mg Tablets in Pakistan

The price of Soranib 200mg Tablet (30’s Imported pack) in Pakistan ranges approximately between:

• Rs. 1,935 – Rs. 8,000 (depending on supplier and availability).

Conclusion

Soranib 200mg Tablets (30 count) are a proven targeted cancer therapy used in the treatment of advanced kidney, liver, and thyroid cancers. By blocking tumor cell growth and blood vessel formation, sorafenib helps slow cancer progression and extend survival.

While effective, it requires strict medical supervision due to potential side effects and drug interactions. Always take Soranib as directed by an oncologist, and ensure proper monitoring throughout treatment.