Description

Premarin Vaginal Cream – Uses, Dosage, Benefits & Side Effects

Premarin Vaginal Cream (0.625mg/g conjugated estrogens) is a hormone replacement therapy (HRT) used to treat moderate to severe vaginal symptoms of menopause, including:

• Vaginal dryness & burning

• Irritation & itching

• Painful intercourse (dyspareunia)

It works by restoring estrogen levels locally in vaginal tissues, helping rebuild and maintain vaginal lining with lower systemic absorption compared to oral or transdermal estrogen therapies.

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What is Premarin Vaginal Cream Used For?

Premarin Vaginal Cream is indicated for:

• Vaginal dryness, irritation, and painful sex after menopause

• Vaginal atrophy due to estrogen deficiency

• Moderate to severe menopausal vaginal symptoms

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How Premarin Vaginal Cream Works

Premarin contains conjugated estrogens derived from natural sources (primarily the urine of pregnant mares). Key components include:

• Sodium Estrone Sulfate

• Sodium Equilin Sulfate

• Other conjugated estrogens (17α-Dihydroequilin, 17α-Estradiol, 17β-Dihydroequilin).

Mechanism of action:

• Estrogens bind to nuclear receptors in vaginal tissue, stimulating gene transcription and protein synthesis.

• Helps rebuild vaginal tissue, improve elasticity, and restore moisture.

• Provides localized estrogen therapy with lower overall absorption, reducing systemic risks.

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Dosage & Administration

• Low Dose (Preferred): 0.5 g intravaginally twice weekly.

• Cyclic Regimen: 0.5 g daily for 21 days on, followed by 7 days off.

• Maximum Dose: 2 g daily (only if prescribed).
  👉 Always use the lowest effective dose for the shortest duration under medical supervision.

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Composition

Each gram of Premarin Vaginal Cream contains:

• 0.625 mg conjugated estrogens

• Base excipients: cetyl alcohol, white wax, mineral oil, glycerin, benzyl alcohol, sodium lauryl sulfate, glyceryl monostearate, and cetyl esters wax.

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Benefits of Premarin Vaginal Cream

• Relieves dryness, irritation, and painful intercourse

• Helps rebuild and maintain vaginal tissue

• Local action with less estrogen absorption compared to tablets or patches

• Clinically proven for moderate to severe menopausal vaginal symptoms

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Risks & Side Effects

Like all estrogen therapies, Premarin carries risks. Possible side effects include:

• Common: Vaginal discharge, itching, irritation, abdominal pain.

• Serious Risks:

  • Endometrial cancer

  • Stroke & blood clots (DVT)

  • Cardiovascular disease

  • Dementia (in older women)
    👉 Women with a history of breast cancer, clotting disorders, or heart disease should use with caution.

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Storage Instructions

• Store at room temperature (as per packaging).

• Keep away from direct heat and light.

• Keep out of reach of children.