Description

Nalorex (Naltrexone) 50mg Tablets – Imported in Pakistan

Nalorex (Naltrexone) 50mg is a prescription medication used in the treatment of alcohol dependence and opioid addiction. Manufactured with the active ingredient naltrexone hydrochloride, it works as a pure opioid antagonist by blocking the euphoric and pleasurable effects of alcohol and opioids, thereby reducing cravings and helping prevent relapse.

Key Uses of Nalorex (Naltrexone)

• Alcohol Dependence: Helps maintain abstinence and reduces the urge to drink.

• Opioid Dependence: Prevents relapse in patients who have stopped using opioids.

• Off-Label Use: In some studies, low-dose naltrexone (LDN) has shown benefits in managing conditions like psoriasis by improving PASI, BSA, and DLQI scores.

Mechanism of Action

• Acts as a competitive antagonist at opioid receptors, with highest affinity for mu-opioid receptors.

• Blocks the “rewarding” effects of alcohol and opioids.

• Reduces cravings and makes alcohol consumption less pleasurable.

• May also influence kappa and delta receptors to a lesser extent.

Dosage & Administration

• Alcohol Dependence: 50mg orally once daily for 12 weeks (on average).

• Opioid Dependence: Start with 25mg daily, then increase to 50mg daily if no withdrawal symptoms occur.

• Extended-Release Injection (Alternative): 380mg intramuscularly every 4 weeks.

• Low-Dose Naltrexone (Research Use): 6mg daily has shown benefits in psoriasis patients in Pakistan.

⚠️ Important: Patients must be opioid-free for 7–10 days before starting treatment to avoid precipitated withdrawal.

Packaging & Price in Pakistan

• Strength: 50mg

• Pack Size: 14 tablets per pack

• Regular Price: ₨ 20,000.00

• Discounted Price: ₨ 18,000.00

Major Benefits

• Reduces cravings for alcohol and opioids.

• Maintains abstinence and prevents relapse.

• May improve quality of life in off-label conditions such as psoriasis.

Safety & Precautions

• Avoid use in patients with acute hepatitis or liver failure.

• Monitor liver function tests regularly due to risk of hepatotoxicity.

• Inform family/friends about increased overdose risk after discontinuation.

• Avoid alcohol while on treatment to reduce dizziness and side effects.

• Naltrexone may interact with opioids, antidepressants, benzodiazepines, cannabinoids, and other opioid antagonists—consult a healthcare provider before use.

Common Side Effects

• Nausea, headache, anxiety, fatigue, and insomnia.

• Possible liver enzyme elevation (requires monitoring).

• Injection form may cause site reactions like pain, swelling, or cellulitis.

Storage Instructions

• Oral Tablets: Store at room temperature (20–25°C), away from heat, light, and moisture.

• Injection (if prescribed): Store refrigerated at 2–8°C. If unrefrigerated, use within 7 days at ≤25°C.