Description

Voriconazole 200mg Injection – Antifungal IV Therapy for Severe Infections

Voriconazole 200mg injection is a broad-spectrum antifungal medication used to treat life-threatening fungal infections when oral therapy is not suitable. Belonging to the triazole antifungal class, voriconazole works by inhibiting fungal cytochrome P-450-dependent 14α-lanosterol demethylation, blocking ergosterol synthesis and weakening the fungal cell membrane.

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Indications – What Voriconazole Injection Treats

Voriconazole 200mg injection is prescribed for serious systemic fungal infections, including:

• Invasive aspergillosis (lung infection caused by Aspergillus species)

• Candidemia in non-neutropenic patients and deep tissue Candida infections

• Serious infections caused by Fusarium species

• Infections caused by Scedosporium apiospermum

Voriconazole is especially effective in patients who are intolerant of or resistant to other antifungal therapies.

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Dosage & Administration

• Loading Dose (Day 1): 6 mg/kg IV every 12 hours

• Maintenance Dose: 4 mg/kg IV every 12 hours

• Duration: Continue IV therapy for at least 7 days, then switch to oral tablets or suspension once the patient stabilizes.

• Reconstitution: Each vial (200mg) must be reconstituted to 10 mg/mL and diluted to ≤5 mg/mL prior to infusion.

• Infusion Time: Administer intravenously over 1–3 hours.

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Contraindications & Drug Interactions

Voriconazole injection should not be used in:

• Patients with hypersensitivity to voriconazole or its excipients

• Concomitant use with rifampin, carbamazepine, long-acting barbiturates, or St. John’s wort (may reduce efficacy)

• Caution with drugs metabolized via CYP450 enzymes (risk of interactions)

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Monitoring & Safety Precautions

Patients on Voriconazole IV therapy should be closely monitored for:

• Renal function → risk of acute kidney injury (monitor serum creatinine)

• Liver function → possible hepatotoxicity

• Vision changes → reversible visual disturbances are common

• Cardiac health → risk of QT prolongation

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Side Effects of Voriconazole 200mg Injection

Common side effects:

• Visual disturbances (blurred vision, photophobia)

• Nausea, vomiting, diarrhea

• Headache, abdominal pain, fever

• Skin rash and photosensitivity

• Abnormal liver function tests

Serious but rare side effects:

• Hepatotoxicity and jaundice

• Renal impairment

• Hallucinations and confusion

• Severe allergic reactions

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Pharmacology & Key Properties

• Active Ingredient: Voriconazole 200mg per vial

• Excipients: 221mg sodium & 3200mg cyclodextrin per vial

• Mechanism of Action: Inhibits fungal ergosterol synthesis → fungistatic against Candida, fungicidal against Aspergillus

• Bioavailability: High oral bioavailability (~96%) when switched to oral therapy

• Onset: Achieves near steady-state plasma levels within 24 hours with loading dose regimen

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Storage & Handling

• Store powder for injection at 20–25°C (68–77°F)

• Reconstituted solution is stable for 24 hours at 2–8°C (refrigerated)

• Keep out of reach of children

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Why Choose Voriconazole 200mg Injection?

• Broad-spectrum coverage against Aspergillus, Candida, Fusarium, and Scedosporium

• Effective alternative for fluconazole-resistant Candida infections

• High efficacy in invasive fungal infections with rapid onset

• Backed by strong clinical evidence for use in immunocompromised and critically ill patients