Description

Ventoxen 100mg (Venetoclax) – Uses, Benefits, Dosage & Side Effects

Ventoxen 100mg is a prescription medication used for the treatment of certain blood cancers, including Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), and in combination therapy for Acute Myeloid Leukemia (AML). It contains the active ingredient Venetoclax, a highly selective B-cell lymphoma-2 (BCL-2) inhibitor that works by blocking cancer cell survival proteins and triggering apoptosis (programmed cell death) in malignant cells.

Key Features of Ventoxen 100mg

• Active Ingredient: Venetoclax

• Strength: 100mg

• Pack Size: 60 tablets (imported)

• Dosage Form: Oral tablet – to be taken once daily with food and water

• Mechanism of Action: Inhibits BCL-2 protein, disrupting cancer cell survival and promoting cell death

• Indications:

  • Chronic Lymphocytic Leukemia (CLL)

  • Small Lymphocytic Lymphoma (SLL)

  • Acute Myeloid Leukemia (AML) (in combination with chemotherapy)

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How Ventoxen 100mg Works

• BCL-2 Protein Role: Cancer cells often overexpress BCL-2, a protein that prevents them from undergoing natural cell death.

• Action of Venetoclax: Ventoxen binds to BCL-2, blocking its function.

• Apoptosis Trigger: This allows pro-apoptotic proteins (like BAX and BIM) to activate, leading to the programmed death of cancer cells.

• Targeted Therapy: Especially effective for patients with genetic abnormalities such as 17p deletion or TP53 mutation, commonly linked with blood cancers.

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Dosage & Administration

• Standard Use: Taken once daily with food.

• CLL/SLL Treatment: Dose gradually increased over the first 5 weeks.

• AML Treatment: Dose titrated over 3–4 days.

• Missed Dose: Take within 8 hours of scheduled time. If more than 8 hours have passed, skip and continue regular schedule.

• Important: Swallow tablets whole. Do not split, crush, or chew.

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Precautions & Safety

• Hydration: Patients must drink 6–8 glasses of water (48–64 oz) daily, especially before treatment initiation and during dose increases, to lower risk of Tumor Lysis Syndrome (TLS).

• Drug Interactions: Avoid strong CYP3A4 inhibitors, which can increase venetoclax toxicity.

• Dietary Restrictions: Do not consume grapefruit, Seville oranges, or grapefruit juice.

• Pregnancy & Breastfeeding:

  • Not safe during pregnancy – may cause fetal harm.

  • Not recommended during breastfeeding (may pass into breast milk).

• Vaccinations: Avoid live vaccines during treatment.

• Monitoring: Regular blood tests are required to monitor white blood cell counts and prevent complications.

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Possible Side Effects

Common side effects include:

• Low white blood cell count (neutropenia)

• Diarrhea

• Nausea & vomiting

• Fatigue

• Upper respiratory tract infections

Serious Risk: Tumor Lysis Syndrome (TLS) – requires close monitoring during initial therapy.

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Storage Instructions

• Store below 30°C in a dry place.

• Keep out of reach of children.

• Dispose of unused tablets safely (do not flush).

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Summary

Ventoxen 100mg (Venetoclax) is an advanced targeted therapy for CLL, SLL, and AML, either as a standalone treatment or in combination with other cancer drugs like rituximab, obinutuzumab, azacytidine, decitabine, or cytarabine. Its targeted mechanism against BCL-2 proteins makes it highly effective in inducing cancer cell death while sparing most healthy cells.

Patients should strictly follow dosing instructions, hydration guidelines, and medical monitoring to minimize risks and maximize treatment effectiveness.