Description

Valcyte 450mg Tablets (60 Count) – Valganciclovir Antiviral for CMV Treatment & Prevention

Valcyte 450mg (Valganciclovir) is a prescription antiviral medicine used to treat and prevent cytomegalovirus (CMV) infections, especially in patients with weakened immune systems, such as those with AIDS or individuals who have undergone organ transplantation. It is most commonly prescribed for CMV retinitis in AIDS patients, a serious infection that can lead to vision loss or blindness

Key Product Information

• Brand Name: Valcyte

• Generic Name: Valganciclovir

• Strength: 450mg

• Pack Size: 60 tablets

• Drug Class: Antiviral medication

• Indications:

  • Treatment of CMV retinitis in AIDS patients

  • Prevention of CMV infections in solid organ transplant recipients

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How Valcyte Works

Valganciclovir is a prodrug that converts into ganciclovir in the body.

1. Conversion: Enzymes in the liver and intestines change valganciclovir into ganciclovir.

2. Activation: Ganciclovir is phosphorylated into its active form inside infected cells.

3. Action: The active form inhibits viral DNA polymerase, blocking viral DNA replication and preventing CMV from multiplying.

This process helps control CMV infections and reduces the risk of disease progression.

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Recommended Dosage

• CMV Retinitis (AIDS patients): 900mg (two 450mg tablets) twice daily for 21 days, followed by 900mg once daily for maintenance.

• Prevention in Transplant Recipients: 900mg once daily, typically for up to 100 days.

⚠️ Dosage may be adjusted for patients with kidney problems. Always follow your physician’s guidance.

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Safety Information & Warnings

• Allergy Alert: Not for patients allergic to valganciclovir, ganciclovir, acyclovir, or penciclovir.

• Use with Caution If You Have:

  • Low blood cell counts

  • Kidney disease (dose adjustment may be required)

  • History of radiation therapy or hemodialysis

• Pregnancy & Breastfeeding: Contraindicated due to potential risk of birth defects and harm to infants. Women must use effective contraception during treatment and for at least 30 days after.

• Driving & Machinery: May cause dizziness, vision changes, or drowsiness. Avoid operating heavy machinery.

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Possible Side Effects

Common: Nausea, vomiting, diarrhea, headache, dizziness, fatigue.
Serious (seek medical help): Bone marrow suppression (low blood counts), kidney problems, or liver issues.

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Storage & Handling

• Store at 15°C–30°C (room temperature), away from moisture and sunlight.

• Keep out of reach of children and pets.

• Do not crush or break tablets; handle with care as the drug is a potential carcinogen/teratogen.

• Dispose of unused medicine safely—do not throw in household waste.

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Appearance

• Tablet Shape: Oval, film-coated

• Color: Pink

• Markings: “VGC” on one side and “450” on the other side