Description

Tucaxen (Tucatinib) 150mg Tablets – Everest Pharmaceuticals

Tucaxen 150mg is a prescription anticancer medicine manufactured by Everest Pharmaceuticals. It contains Tucatinib, a highly selective kinase inhibitor used in the treatment of HER2-positive locally advanced or metastatic breast cancer. Tucaxen is usually prescribed in combination with trastuzumab and capecitabine for patients who have previously received anti-HER2 therapies.

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Composition

• Each film-coated tablet contains: Tucatinib 150 mg

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Indications

• Treatment of HER2-positive metastatic breast cancer

• For patients with locally advanced unresectable tumors

• Typically prescribed after failure of prior anti-HER2 therapies

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Dosage & Administration

• Recommended dose: 300 mg twice daily (two 150mg tablets, about 12 hours apart)

• Can be taken with or without food

• Tablets should be swallowed whole with water (do not crush or chew)

• Dosage must be determined by an oncologist

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Mechanism of Action

• Tucatinib is a tyrosine kinase inhibitor that selectively blocks the HER2 and HER3 signaling pathways

• By inhibiting these pathways, it helps stop the growth and spread of cancer cells

• Works best when used in combination therapy with trastuzumab and capecitabine

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Common Side Effects

Some patients may experience mild to moderate side effects, including:

• Diarrhea

• Hand-foot syndrome (redness/swelling of palms and soles)

• Nausea & vomiting

• Fatigue and headache

• Liver function abnormalities

• Mouth sores or pain

• Loss of appetite & weight loss

• Abdominal pain, muscle or joint pain, rash

• Anemia (low red blood cell count)

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Serious Side Effects

Seek medical attention immediately if you notice:

• Severe liver damage (jaundice, dark urine, upper abdominal pain)

• High risk of infections (fever, persistent sore throat, unusual bleeding or bruising)

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Precautions & Warnings

• Pregnancy & Breastfeeding: Not recommended due to potential harm to the baby.

• Driving or Operating Machinery: Avoid, as Tucaxen may cause dizziness or fatigue.

• Drug Interactions: May interact with antifungals, antibiotics, anticonvulsants, and herbal supplements. Always consult your doctor before combining with other medicines.

• Liver Monitoring: Regular liver function tests are required during treatment.

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Storage

• Store at room temperature (15–25°C)

• Keep away from moisture, heat, and direct sunlight

• Store out of reach of children

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Product Details

• Brand Name: Tucaxen

• Generic Name: Tucatinib

• Strength: 150 mg

• Pack Size: 30 Tablets

• Manufacturer: Everest Pharmaceuticals

• Therapeutic Class: Anticancer, HER2-targeted therapy