Description

Palbocent 125 mg Capsules (Palbociclib) – Price, Uses, Side Effects in Pakistan

Palbocent 125 mg capsules contain Palbociclib, a targeted therapy for the treatment of hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer. It is manufactured by Incepta Pharmaceutical Ltd. and widely available in Pakistan at a much lower cost compared to international brands.

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Palbocent 125 mg Price in Pakistan

• Approximate Price: PKR 45,000 per pack (21 capsules)

• Comparison:

  • Ibrance (Pfizer) – ~PKR 200,000

  • Palbonix – ~PKR 110,000
    ✅ Palbocent is one of the most cost-effective Palbociclib brands in Pakistan.

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Indications (Uses)

Palbocent is prescribed for:

• HR+/HER2- advanced or metastatic breast cancer

• Used in combination with hormone therapies such as aromatase inhibitors (letrozole, anastrozole) or fulvestrant

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Dosage & Administration

• Standard Dose: 125 mg orally once daily

• Cycle: 21 days on treatment → 7 days off (28-day cycle)

• Instructions: Take with food at the same time each day
  ⚠️ Dosage adjustments may be required depending on blood counts and tolerance.

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Mechanism of Action

• Palbociclib is a CDK4/6 inhibitor

• It blocks cell cycle progression (G1 → S phase)

• Prevents cancer cell division and promotes tumor growth arrest

• Works best with antiestrogen therapies, improving survival outcomes

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Side Effects of Palbocent

Common:

• Neutropenia (low white blood cells)

• Fatigue

• Nausea & diarrhea

• Hair thinning

• Mouth sores

Serious:

• Increased risk of infections due to low immunity

• Requires regular blood monitoring (especially during the first 2 cycles)

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Warnings & Precautions

• ❌ Pregnancy: Can cause fetal harm – avoid use during pregnancy & breastfeeding

• ❌ Alcohol & Grapefruit: Avoid as they may increase side effects

• ⚠️ Drug Interactions: Palbocent is metabolized by CYP3A – avoid strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) and strong inducers (rifampin, phenytoin, St. John’s Wort)

• ⚠️ Driving: May cause dizziness & fatigue, avoid operating heavy machinery

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Storage Instructions

• Store below 30°C in a dry place

• Keep away from sunlight & moisture

• Out of reach of children

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Why Choose Palbocent?

• Affordable alternative to Ibrance & Palbonix

• Clinically proven to improve progression-free survival in breast cancer patients

• Effective in combination with hormone therapies

• Manageable side effects with proper monitoring

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Disclaimer

Palbocent 125 mg (Palbociclib) is a prescription-only cancer medicine. It must be taken under the supervision of a qualified oncologist. This article is for educational purposes only and not a substitute for professional medical advice.