Description

Norditropin NordiFlex 5 mg/1.5 ml – Human Growth Hormone Injection Pen

Generic Name: Somatropin (r-hGH)
Brand Name: Norditropin NordiFlex
Formulation: Solution for injection in a multidose pre-filled pen
Strength: 5 mg/1.5 ml (3.3 mg/ml)
Manufacturer: Novo Nordisk

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Product Overview

Norditropin NordiFlex 5 mg/1.5 ml is a prescription growth hormone therapy used for both children and adults with growth hormone deficiency (GHD). It contains somatropin, a recombinant human growth hormone (r-hGH) that is identical to the natural hormone produced in the pituitary gland.

The pre-filled, multidose NordiFlex pen allows for accurate, convenient, and sterile administration, with dosing increments as small as 0.025 mg.

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Indications – What Norditropin is used for

• Children

  • Growth failure due to insufficient secretion of natural growth hormone

  • Short stature associated with Turner syndrome, Noonan syndrome, Prader-Willi syndrome

  • Growth delay in children born small for gestational age (SGA)

  • Idiopathic short stature (ISS)

• Adults

  • Replacement therapy for adults with growth hormone deficiency

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Mechanism of Action – How Norditropin Works

• Growth stimulation: Increases production of IGF-1 (Insulin-like Growth Factor 1), which promotes skeletal growth, protein synthesis, and cell division.

• Metabolic benefits: Improves nitrogen retention, fat mobilization, and glucose metabolism.

• Body composition: Increases lean muscle mass while reducing fat mass.

• Additional effects: Enhances bone density, cardiovascular health, and overall quality of life.

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Dosage & Administration

• Children with GHD: 0.17–0.24 mg/kg/week (0.024–0.034 mg/kg/day)

• Prader-Willi syndrome: 0.24 mg/kg/week (0.034 mg/kg/day)

• Turner syndrome, Noonan syndrome, ISS, SGA: Up to 0.47 mg/kg/week (0.067 mg/kg/day)

• Adults with GHD: Individualized dosing based on weight and treatment goals

Important Notes:

• Maximum dose per injection: 1.5 mg somatropin

• Delivered in increments of 0.025 mg

• Administer using the color-coded NordiPen (orange) for correct dosing

• Inject subcutaneously; avoid shaking the pen vigorously

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Side Effects

Common side effects include:

• Cold symptoms, headache, mild fever

• Injection site pain or redness

• Muscle or joint pain

• Swelling of hands or feet

• Fatigue

Serious but rare risks:

• Increased intracranial pressure

• Pancreatitis

• Risk of malignancy recurrence

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Contraindications & Warnings

• Not for patients with acute critical illness or active malignancy

• Contraindicated in patients allergic to somatropin or excipients

• Not to be used for growth promotion in children with closed growth plates

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Storage Instructions

• Before first use: Refrigerate at 2–8°C (36–46°F). Do not freeze.

• After first use:

  • Store in refrigerator for up to 4 weeks

  • Can be stored at room temperature (≤25°C/77°F) for up to 3 weeks

• Keep away from sunlight and out of reach of children

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Key Benefits of Norditropin NordiFlex 5 mg/1.5 ml

• Convenient pre-filled disposable pen for easy use

• Delivers precise micro-doses of somatropin

• Helps children achieve catch-up growth and final height potential

• Restores normal growth hormone levels in adults

• Improves body composition, metabolism, and quality of life