Description

Midodrine 2.5mg Tablets (20 Count) – Treatment for Severe Orthostatic Hypotension

Midodrine 2.5mg Tablets are a prescription medication used to treat severe orthostatic hypotension caused by autonomic nervous system dysfunction, especially when other corrective factors have been ruled out. This condition is marked by a significant drop in blood pressure upon standing, leading to dizziness, lightheadedness, blurred vision, fatigue, or fainting.

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Product Details

• Dosage Strength: 2.5mg per tablet

• Quantity: 20 tablets per bottle

• Active Ingredient: Midodrine Hydrochloride 2.5mg

• Pharmacological Class: Vasopressor and antihypotensive agent

• Trade Names: Amatine, Proamatine, Gutron, and others

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How Midodrine Works

Midodrine is a prodrug, converted in the body into its active metabolite desglymidodrine. This metabolite is a selective alpha-1 adrenergic receptor agonist, which works by:

• Constricting blood vessels (vasoconstriction): Increases vascular tone and blood pressure.

• Improving upright blood pressure: Prevents dizziness and fainting when standing.

• Minimal CNS effects: Desglymidodrine poorly crosses the blood-brain barrier, avoiding central nervous system side effects.

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Onset & Duration

• Onset of Action: 45–90 minutes after oral administration.

• Peak Effect: Around 1 hour post-dose.

• Duration: Maintains elevated blood pressure for 2–3 hours.

• Food Interaction: Food does not affect absorption or effectiveness.

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Indications

• Primary Use: Treatment of severe symptomatic orthostatic hypotension due to autonomic dysfunction.

• Benefits:

  • Reduces dizziness and fainting episodes.

  • Increases standing blood pressure.

  • Improves stability, safety, and daily functioning.

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Dosage & Administration

• Starting Dose: 2.5mg, 2–3 times daily.

• Titration: Dose may be increased weekly until an optimal response is achieved.

• Maximum Dose: 30mg daily, divided into multiple doses.

• Administration Guidelines:

  • Take during daytime when upright and active.

  • Last dose should be taken at least 4 hours before bedtime to avoid supine hypertension.

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Contraindications

Midodrine 2.5mg is not recommended for patients with:

• Hypertension

• Severe organic heart disease or congestive heart failure

• Acute or severe renal impairment (creatinine clearance <30 ml/min)

• Urinary retention or prostate hypertrophy

• Thyrotoxicosis, pheochromocytoma, or hyperthyroidism

• Narrow-angle glaucoma or proliferative diabetic retinopathy

• Vasovagal hypotension or spastic/obliterative vascular disease

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Side Effects

Common side effects may include:

• Tingling or itching of the scalp

• Goosebumps (piloerection)

• Headache

• Urinary retention

• Supine hypertension (increased blood pressure while lying down)

Important: Patients must undergo regular blood pressure monitoring in both supine and sitting positions to ensure safety.

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Storage Information

• Store at 20–25°C (68–77°F)

• Protect from light and moisture

• Keep out of reach of children

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Key Benefits of Midodrine 2.5mg

• Effective treatment for orthostatic hypotension

• Fast onset with peak effect in about 1 hour

• Helps reduce dizziness, fainting, and fatigue

• Improves quality of life for patients with autonomic dysfunction

• Convenient 20-count bottle for short-term use or dose titration