Description

Leukeran (Chlorambucil) 2mg Tablets – 25’s Pack

Overview:
Leukeran is a prescription chemotherapy medication that contains Chlorambucil 2mg, an alkylating agent widely used in the treatment of blood cancers. It is primarily indicated for Chronic Lymphocytic Leukemia (CLL), Hodgkin lymphoma, and Non-Hodgkin lymphoma. By interfering with DNA replication, Leukeran slows down or stops the growth of cancer cells, helping to manage the progression of these conditions.

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Key Details

• Brand Name: Leukeran

• Generic Name: Chlorambucil

• Strength: 2 mg tablets

• Pack Size: 25 tablets per pack

• Approximate Price: ₨10,000 (as of August 2023, Pakistan)

• Availability: Licensed pharmacies in Pakistan (prescription required)

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How Leukeran Works

• DNA Alkylation: Chlorambucil binds to DNA and disrupts its structure, preventing cell division.

• Apoptosis Induction: Triggers programmed cancer cell death (apoptosis) through p53 and Bax protein pathways.

• Bifunctional Action: Cross-links DNA strands, making cancer cells unable to repair themselves effectively.

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Uses / Indications

Leukeran 2mg is commonly prescribed for:

• Chronic Lymphocytic Leukemia (CLL)

• Hodgkin’s Lymphoma

• Non-Hodgkin’s Lymphoma

• Other hematological malignancies (as directed by a doctor)

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Dosage & Administration

• Form: Oral tablets

• Route: Taken by mouth, usually once daily on an empty stomach (1 hour before or 3 hours after meals).

• Duration: Treatment typically lasts 3–6 weeks, depending on patient response.

• Supervision: Must be taken strictly under oncologist/hematologist supervision.

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Side Effects & Risks

Like other chemotherapy drugs, Leukeran may cause side effects:

• Common: Nausea, vomiting, fatigue, loss of appetite.

• Serious: Bone marrow suppression (low white cells, anemia, thrombocytopenia), liver toxicity, infertility, seizures (rare).

• Long-Term Risks: Increased risk of secondary cancers.

⚠️ Pregnancy Warning: Chlorambucil can harm a developing fetus (Category D). It is contraindicated during pregnancy and breastfeeding.

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Drug Interactions

• Avoid with: Nalidixic acid, fingolimod, lomustine, obinutuzumab, oxaliplatin, olaparib, and other strong immunosuppressants.

• May increase risk of myelosuppression and infections when used with other chemotherapy drugs.

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Storage Guidelines

• Store in a refrigerator at 2°C–8°C (36°F–46°F).

• Keep in original packaging, away from light and moisture.

• Keep out of reach of children and pets.

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Why Choose Leukeran (Chlorambucil)?

• Effective treatment for leukemia and lymphoma.

• Oral chemotherapy – convenient compared to IV treatments.

• Proven history of clinical use since 1957.

• Helps improve quality of life for patients by controlling disease progression.

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Safety Advice

• Always follow your doctor’s prescribed dose.

• Do not stop treatment without medical guidance.

• Regular blood monitoring is essential during therapy.

• Discuss fertility preservation if planning a family.