Description

Ibruxen (Ibrutinib) 140 mg Capsules – Overview

Ibruxen 140 mg Capsules contain the active ingredient Ibrutinib, a Bruton’s Tyrosine Kinase (BTK) inhibitor used in the treatment of certain blood cancers. As a generic version of Imbruvica, Ibruxen offers a more cost-effective treatment option while maintaining the same clinical effectiveness.

By blocking BTK, Ibruxen disrupts signaling pathways that help cancer cells grow and survive, leading to reduced disease progression in conditions such as Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL).

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Indications – What is Ibruxen 140 mg used for?

Ibruxen (Ibrutinib) 140 mg is prescribed for the treatment of:

• Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)

• Mantle Cell Lymphoma (MCL) – for patients who have received at least one prior therapy

• Waldenström’s Macroglobulinemia (WM)

• Marginal Zone Lymphoma (MZL) – for patients requiring systemic therapy

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How Ibruxen Works

• Ibrutinib selectively inhibits Bruton’s Tyrosine Kinase (BTK).

• Blocks B-cell receptor signaling, which is essential for survival of malignant B cells.

• Induces apoptosis (programmed cell death) of cancer cells.

• Reduces cancer cell adhesion, migration, and proliferation.

• Provides targeted therapy with proven anti-cancer activity.

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Recommended Dosage of Ibruxen 140 mg

The dose depends on the type of cancer being treated:

• CLL / SLL / Waldenström’s Macroglobulinemia (WM):
  420 mg once daily (three 140 mg capsules).

• Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL):
  560 mg once daily (four 140 mg capsules).

• Combination Therapy (with bendamustine + rituximab for CLL/SLL):
  420 mg once daily.

💊 Capsules should be taken orally, once daily, with water and continued until disease progression or unacceptable toxicity.

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Key Benefits of Ibruxen Capsules

• Effective treatment for multiple B-cell malignancies.

• Generic version of Imbruvica – more affordable option.

• Convenient once-daily oral capsule.

• Proven to slow disease progression and improve outcomes.

• Available in bottles of 120 capsules for extended supply.

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Storage Instructions

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.

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Important Safety Information

• Common side effects: diarrhea, fatigue, nausea, bruising, muscle/joint pain, and upper respiratory infections.

• Serious risks: bleeding, infections, heart rhythm problems (atrial fibrillation), hypertension, and tumor lysis syndrome.

• Inform your doctor about all medications being taken to avoid drug interactions.

• Regular monitoring and medical follow-up are essential during treatment.