Description

Amphotericin B 50mg Injection (AmBisome) in Pakistan – Uses, Price, Dosage & Side Effects

Overview
Amphotericin B 50mg Injection, also known as AmBisome, is a prescription antifungal medication used to treat serious, potentially life-threatening fungal infections. It is also effective against some protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis.

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Amphotericin B 50mg Injection Price in Pakistan

• AmBisome 50mg Injection: ~Rs. 1,000

• Other brands: Range from Rs. 618 to Rs. 20,000 depending on brand and manufacturer

• Generic brand (Amphotret): Around Rs. 1,000, making it more affordable for patients

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Medical Uses

Amphotericin B is widely prescribed for:

• Severe systemic fungal infections including:

  • Aspergillosis

  • Cryptococcosis

  • Candidiasis

  • Other invasive fungal diseases

• Drug-resistant fungal infections – low resistance rate makes it highly effective

• Life-threatening protozoan infections such as:

  • Visceral leishmaniasis

  • Primary amoebic meningoencephalitis

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Active & Inactive Ingredients

• Active Ingredient: Amphotericin B – potent antifungal agent (50 mg per vial)

• Inactive Ingredients:

  • Deoxycholic acid (38.75 mg per 10 mL)

  • Dibasic sodium phosphate (18.85 mg per 10 mL)

  • Monobasic sodium phosphate monohydrate (1.02 mg per 10 mL)

  • Phosphoric acid & sodium hydroxide (pH adjustment)

  • Nitrogen (for vial stability)

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Dosage & Administration

• Recommended Dose: 0.25–0.3 mg/kg, given intravenously (IV) once daily or every other day

• Maximum Dose: 1.5 mg/kg per day (exceeding this increases toxicity risk)

• Infusion Duration: Slowly over 2–6 hours

• Treatment Duration: Weeks to months depending on infection type and patient response

• Requires close monitoring due to potential side effects

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Storage Instructions

• Store vials at 2–8°C (refrigerated)

• Protect from light, do not freeze

• Reconstituted solution: Stable for 24 hours (refrigerated)

• Diluted infusion solution: Stable for 24 hours (refrigerated) or 6 hours at room temperature

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Side Effects of Amphotericin B Injection

Common:

• Infusion-related reactions – fever, chills, nausea, vomiting, headache

• Tiredness and weakness

Serious (require monitoring):

• Kidney toxicity

• Liver dysfunction

• Electrolyte imbalance

• Severe infusion reactions

⚠️ Premedication may be recommended to reduce infusion-related side effects.

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Patient Reviews & Effectiveness

• Average Rating: 3.5/5 stars (based on 7 reviews)

• Effectiveness: Rated 1–5 stars, majority report positive outcomes

• Ease of Use: Mixed ratings due to long infusion times and hospital monitoring

• Overall Feedback: Effective for severe fungal infections, but side effects and prolonged treatment course are common challenges