Description

Actilyse 50mg Injection (Alteplase) – Uses, Dosage, Side Effects & Price in Pakistan

Actilyse 50mg Injection is a thrombolytic (clot-dissolving) medicine that contains the active ingredient Alteplase. It is prescribed for the emergency treatment of life-threatening conditions caused by blood clots, including heart attack (myocardial infarction), acute ischemic stroke, and pulmonary embolism.

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What is Actilyse Used For?

Actilyse is a prescription-only medication used in hospitals under strict medical supervision. It helps restore blood flow by dissolving clots inside blood vessels.

• ✅ Heart Attack (Myocardial Infarction): Breaks down clots blocking heart arteries, restoring blood flow and minimizing heart muscle damage.

• ✅ Acute Ischemic Stroke: Dissolves clots in the brain’s arteries, restoring blood flow and reducing the risk of permanent disability.

• ✅ Pulmonary Embolism: Treats blood clots in the lungs, improving oxygen delivery and reducing life-threatening risks.

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How Actilyse (Alteplase) Works

Actilyse contains Alteplase, a tissue plasminogen activator (tPA). It works by converting plasminogen into plasmin, an enzyme that breaks down fibrin (the structural framework of blood clots). This process helps dissolve clots and restores normal blood circulation.

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Actilyse Dosage & Administration

The dose of Actilyse 50mg Injection is based on body weight, with a maximum of 90–100 mg. It is administered only by healthcare professionals.

• Initial Dose: 10% of the total dose given as an IV bolus

• Remaining Dose: 90% infused intravenously over 60 minutes

• Formulation: Powder for solution, reconstituted before use

⚠️ Actilyse must be given as soon as possible after the onset of symptoms for best results (especially in stroke treatment).

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Ingredients in Actilyse 50mg Injection

• Active Ingredient: Alteplase (tissue plasminogen activator, tPA)

• Excipients: Arginine, Phosphoric acid, Polysorbate 80, Sucrose

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Side Effects of Actilyse Injection

Like all powerful thrombolytic agents, Actilyse carries the risk of serious side effects, especially bleeding.

Common Side Effects:

• Bleeding (nose, gums, urine, injection site)

• Low blood pressure (hypotension)

• Nausea or vomiting

• Fever or allergic reactions

Serious Side Effect:

• Intracranial hemorrhage (bleeding in the brain) – requires immediate medical attention

⚠️ Because of these risks, Actilyse is only given under strict hospital monitoring.

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Storage Instructions

• Store powder below 25°C, protected from light

• After mixing, keep solution at 2–8°C for up to 24 hours

• Use reconstituted solution as soon as possible

• Do not freeze