Description

Imuran (Azathioprine) 50mg Tablets – Uses, Dosage & Price in Pakistan

Imuran 50mg tablets contain the active ingredient Azathioprine, a well-established immunosuppressant medication. It works by reducing the activity of the immune system to help prevent organ rejection in transplant patients and manage autoimmune diseases such as rheumatoid arthritis, lupus, Crohn’s disease, ulcerative colitis, and others.

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What is Imuran Used For?

Imuran is prescribed in the following conditions:

🔹 Transplant Medicine

• Prevents rejection in kidney, liver, and heart transplants

• Helps the body accept the new organ by suppressing immune response

🔹 Autoimmune Disorders

• Rheumatoid arthritis

• Systemic lupus erythematosus (SLE)

• Inflammatory bowel disease (IBD): Crohn’s disease & ulcerative colitis

• Other chronic autoimmune conditions

🔹 Steroid-Sparing Therapy

• Reduces the required dose of corticosteroids

• Minimizes long-term steroid side effects

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How Imuran Works

• Prodrug Mechanism: Azathioprine is converted in the body to 6-mercaptopurine (6-MP)

• Immune Suppression: Inhibits DNA and RNA synthesis in rapidly dividing T and B lymphocytes

• Result: Suppresses abnormal immune responses, prevents organ rejection, and reduces autoimmune flare-ups

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Dosage & Administration

⚠️ Dosage must always be individualized under doctor supervision.

• Organ Transplant Patients:

  • Initial dose: 3–5 mg/kg/day

  • Maintenance: 1–3 mg/kg/day

• Autoimmune Conditions (e.g., RA, IBD):

  • Starting dose: 1 mg/kg/day

  • May increase up to 2.5 mg/kg/day

• Administration:

  • Taken once or twice daily with food to reduce stomach upset

  • Full therapeutic effect may take 2–3 months

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Side Effects & Precautions

Common Side Effects:

• Nausea, vomiting, diarrhea

• Loss of appetite

• Tiredness or mild hair loss

Serious Risks (require monitoring):

• Bone marrow suppression (low blood counts)

• Increased risk of infections

• Long-term use may raise risk of lymphoma or skin cancer

Monitoring Required:

• Regular blood tests to check blood counts and liver function

• Genetic testing (TPMT/NUDT15) may be recommended to reduce toxicity risk

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Storage Instructions

• Store below 30°C in the original container

• Protect from light, heat, and moisture

• Keep out of reach of children

• Do not use after the expiry date

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Imuran Price in Pakistan

💊 Imuran 50mg tablets (100’s pack) are available as imported medication in Pakistan. Price may vary depending on supplier and availability—check with authorized pharmacies or distributors for the latest cost.

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Key Highlights

✅ Prevents organ transplant rejection
✅ Effective in autoimmune diseases like RA, lupus & IBD
✅ Long-term maintenance therapy option
✅ Requires strict medical supervision and monitoring