Description

Topamax 25 mg Tablets (Topiramate) – Uses, Dosage, Side Effects & Price in Pakistan

Topamax 25 mg tablets contain Topiramate, a well-known anticonvulsant and migraine prevention medicine. It is prescribed for the treatment of epilepsy (seizures) in adults and children, and for the prevention of migraine headaches in adults and children over 12 years.

Manufactured by Janssen Pharmaceuticals, Topamax is available in 50-count bottles and comes in film-coated white, round tablets, debossed with “TOP” on one side and “25” on the other.

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Key Uses of Topamax 25 mg

• Treatment of Seizures (Epilepsy):

  • Monotherapy or adjunct therapy in adults and children aged 6 years and above.

• Migraine Prevention:

  • Reduces the frequency and severity of migraine attacks in adults and adolescents aged 12 years and older.

• Other Off-Label Uses (under doctor’s supervision):

  • Management of alcohol dependence

  • Treatment of essential tremor

  • Weight management (due to appetite suppression effect)

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Recommended Dosage & Administration

• Starting Dose: 25–50 mg once daily at bedtime for one week.

• Titration: Increase weekly by 25–50 mg, taken in two divided doses, until optimal therapeutic effect is reached.

Maintenance Dose (Guideline):

• Monotherapy for Epilepsy (Adults & Children 10+ years): Up to 400 mg/day in two divided doses.

• Adjunctive Therapy for Epilepsy (Adults): 200–400 mg/day.

• Children (2–9 years): 5–9 mg/kg/day, divided into two doses.

• Migraine Prevention (Adults & Children 12+ years): 100 mg/day in two divided doses.

💊 Always follow your doctor’s prescribed dose. Do not adjust or stop without medical advice.

 

How Topamax (Topiramate) Works

The exact mechanism is not fully understood, but Topamax may work through:

• Blocking voltage-gated sodium channels

• Enhancing activity of GABA (gamma-aminobutyric acid) neurotransmitters

• Reducing activity at glutamate receptors (AMPA/kainate)

• Inhibiting carbonic anhydrase enzyme

These combined actions help control seizures and prevent migraines.

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Side Effects of Topamax 25 mg

Common Side Effects:

• Tingling in hands/feet

• Fatigue or drowsiness

• Loss of appetite, weight loss

• Cognitive effects (difficulty concentrating, memory problems)

Serious Side Effects (Seek Medical Help):

• Vision problems or sudden eye pain

• Severe mood changes or depression

• Kidney stones (stay well hydrated)

• Metabolic acidosis (unexplained tiredness, irregular heartbeat)

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Warnings & Precautions

• Pregnancy: Avoid use unless strictly prescribed – linked to birth defects (oral clefts, growth restriction, autism spectrum risk).

• Children: Safe for seizure treatment above 6 years, migraine prevention above 12 years.

• Hydration: Drink plenty of fluids to prevent kidney stones.

• Drug Interactions: May interact with oral contraceptives, other anti-epileptic medicines, or alcohol.

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Storage Instructions

• Store at room temperature (15°C – 30°C).

• Keep in a tightly closed container, protected from moisture and light.

• Keep out of reach of children.