Description

GNC Niacin 250mg in Pakistan – Price, Benefits, Uses, Dosage & Side Effects

GNC Niacin 250mg is an imported dietary supplement that provides 250 mg of niacin (vitamin B3) per serving. Niacin is an essential B-vitamin that supports healthy cholesterol levels, blood vessel function, energy metabolism, and antioxidant protection.

✅ Pack Size: 100 vegetarian-friendly tablets
✅ Strength: 250 mg niacin per tablet
✅ Imported from the USA
✅ Price in Pakistan: Varies by retailer

Key Benefits of GNC Niacin 250mg

• Supports Healthy Blood Lipid Profile: Reduces LDL (bad cholesterol), VLDL, and triglycerides while raising HDL (good cholesterol).

• Promotes Heart & Vascular Health: Improves circulation, supports endothelial function, and lowers arterial inflammation.

• Boosts Energy Metabolism: Helps convert food into energy by acting as a precursor for NAD and NADP coenzymes.

• Antioxidant Protection: Neutralizes free radicals and reduces oxidative stress.

• Anti-Inflammatory Support: Inhibits cytokines and reduces arterial plaque buildup risk.

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Key Ingredients

Each tablet of GNC Niacin 250mg contains:

• Niacin (Vitamin B3): 250 mg

• Dicalcium Phosphate

• Microcrystalline Cellulose

• Rice Bran Powder (Oryza sativa)

• Stearic Acid (vegetable source)

• Croscarmellose Sodium

Vegetarian-friendly | Non-GMO | Gluten-Free

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How Niacin Works (Mechanism of Action)

1. Lipid-Modifying Effects:

   • Lowers LDL, VLDL, and triglycerides.

   • Increases HDL cholesterol (good cholesterol).

2. Anti-Inflammatory Properties:

   • Reduces cytokine production.

   • Slows down progression of atherosclerosis.

3. Vasodilation & Endothelial Support:

   • Stimulates nitric oxide release, improving circulation.

   • Enhances blood vessel elasticity and reduces blood pressure.

4. Antioxidant Action:

   • Protects cells from free radical damage.

   • Reduces oxidative stress linked to heart disease.

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Niacin Chemical Structure

• Name: Nicotinic Acid (Vitamin B3)

• Formula: C₆H₅NO₂

• Molecular Weight: 123.11 g/mol

• Structure: Pyridine ring with a carboxylic acid group (COOH) at the 3-position

• Forms: Nicotinic acid & nicotinamide (both convert to NAD/NADP in the body)

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Recommended Dosage & Usage

• Adults: Take 1–2 tablets daily with a meal or snack (250–500 mg daily).

• Do not exceed recommended dosage without medical advice.

• Store in a cool, dry place away from heat and moisture.

⚠️ Avoid taking on an empty stomach to reduce flushing and stomach upset.

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Safety & Precautions

• Consult a doctor if you have diabetes, liver disease, kidney issues, ulcers, gout, or heart conditions.

• Alcohol consumption should be limited, as it increases the risk of flushing and liver stress.

• High doses (above 1,000 mg/day) may cause side effects like flushing, rashes, dizziness, and liver problems.

• Not recommended during pregnancy or breastfeeding unless prescribed.

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Drug Interactions

Niacin may interact with:

• Statins (atorvastatin, simvastatin, lovastatin): May increase muscle problems.

• Bile acid sequestrants (cholestyramine, colestipol): Reduce niacin absorption.

• Diabetes medications (insulin, metformin, glyburide, glipizide): May raise blood sugar.

• Blood thinners (warfarin): May increase bleeding risk.

• Tetracycline antibiotics: Reduced absorption—avoid taking together.

• Alpha-blockers: May cause low blood pressure when combined.

• Nicotine patches: May worsen flushing.

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Pregnancy & Breastfeeding

• RDA in Pregnancy: 18 mg/day

• RDA in Breastfeeding: 17 mg/day

• Normal dietary intake is safe, but high doses are not recommended.

• Always consult a doctor before supplementation during pregnancy or lactation.

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Possible Side Effects of GNC Niacin 250mg

• Flushing (warmth, redness, itching)

• Headache or dizziness

• Stomach upset or nausea

• Rare: liver problems at very high doses

💡 To reduce flushing: take with food, avoid alcohol/spicy foods, and start with a lower dose.